Why may I need allogeneic stem cell transplant

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Until now, bone marrow transplantation is limited in patients who can find a donor with a matching tissue type for transplantation between individuals who truly unmatched causing graft-versus-host disease, a condition that is often lethal in which the immune system of a transplant recently failed to recognize and attack the recipient's body. When the stem cells collected from other people, the cells are tested to make sure they fit with your cells. A transplant from an unrelated donor are more likely to cause problems. If the stem cells derived from donated bone marrow or umbilical cord blood, it usually takes about 18 days for bone marrow to start producing new blood cells. If the cells derived from donated blood, may not take that long.

The researchers have created a new procedure known as a bone marrow transplant half-fit. Because half of the match took place between all parents and your own children, almost everyone needs a bone marrow transplant now have a suitable donor. This development has dramatically improved the survival rate of the recipient bone marrow. The use of other types of stem cells, including embryonic stem cells and cells induced pluripotent stem cells made from adult still experimental. Scientists harness the natural ability of the virus to enter cells, using them as a vehicle to deliver genes. One disadvantage to do so, however, is the increased risk of cancer in the cells as the virus combines with the cell's DNA. Researchers are experimenting with different shipping methods to reduce this risk.

The use of a virus to make the cells induced pluripotent stem also seems to cause problems. Initially, the scientists expressed through viral protein-a potentially dangerous technology that has caused great concern. Cells derived in this way, when subsequently transplanted, has been shown to cause tumors in mice. Scientists are developing a new method of creating stem cells. One major concern is the real relationship between stem cells and cancer progression. Stem cell pluripotency seems to be a double-edged sword: if the stem cells divide uncontrollably in the body, they can cause cancer, but if the same cells divide under the control of the plate, they have the potential to become specialized cells for transplantation to treat the disease.